Neuronal Lamin regulates motor circuit integrity and controls motor function and lifespan

Activity Regulates Neuronal Connectivity and Function in the C. elegans Motor Circuit: A Dissertation

Cerebral Palsy: Motor Types, Gross Motor Function and Associated Disorders

Objectives: Cerebral palsy (CP) describes a group of disorders in the development of movement and posture in the developing brain. The main aim of this study was to determine the distribution of motor impairment and associated disorders in a population of children with CP. Methods: This study was carried out in 2011 during three months, on 200 CP children. Multiple sources of ascertainment w...

PTL-1 regulates neuronal integrity and lifespan in C. elegans.

Protein with tau-like repeats (PTL-1) is the sole Caenorhabditis elegans homolog of tau and MAP2, which are members of the mammalian family of microtubule-associated proteins (MAPs). In mammalian neurons, tau and MAP2 are segregated, with tau being mainly localised to the axon and MAP2 mainly to the dendrite. In particular, tau plays a crucial role in pathology, as elevated levels lead to the f...

Lifespan trajectory of myelin integrity and maximum motor speed.

OBJECTIVE Myelination of the human brain results in roughly quadratic trajectories of myelin content and integrity, reaching a maximum in mid-life and then declining in older age. This trajectory is most evident in vulnerable later myelinating association regions such as frontal lobes and may be the biological substrate for similar trajectories of cognitive processing speed. Speed of movement, ...

FET proteins regulate lifespan and neuronal integrity

The FET protein family includes FUS, EWS and TAF15 proteins, all of which have been linked to amyotrophic lateral sclerosis, a fatal neurodegenerative disease affecting motor neurons. Here, we show that a reduction of FET proteins in the nematode Caenorhabditis elegans causes synaptic dysfunction accompanied by impaired motor phenotypes. FET proteins are also involved in the regulation of lifes...